A big benefit of having 250GB of hard drive space? Being able to install and enjoy using virtual machines.
I just installed a trial of VMWare Fusion and plan on installing both Windows XP and Ubuntu virtual machines on my Macbook. That should help me test or use just about any software out there.
I also would like to get a Windows Server 2003 (or maybe 2008?) virtual machine going, so I can practice my Microsoft skills. But getting a legal license for that is probably going to be too pricey.